论文部分内容阅读
作者采用对照试验研究瑞典的6岁儿童在3、5和12月龄时接种b型流感杆菌结合菌苗一破伤风类毒素(Hib-TT)后的血清Hib抗体持久性,并比较免疫儿童和未免疫儿童体内的Hib抗体浓度.作者于1987年用Hib-TT接种85名婴儿(分别于 3、5和 12月龄时接种),其中40名婴儿每剂接受7.5μg的Hib荚膜多糖.另45名则接受15μg的Hib.结果显示,30个月时两组的Hib抗体几何平均浓度(GMC)分别为0.92μg/ml和1.69μg/ml,97%的儿童的抗体浓度高于推荐的保护水平(0.15μg/ml),51%的儿童的抗体浓度高于1.0μg/ml.作者在这些儿童6岁时对其中的70岁儿童进行Hib抗体检测,并挑选85名未接种过Hib-TT且未感染过Hib的儿童作对照.
The authors used a controlled trial of persistence of serum Hib antibodies in children aged 6 years at 5, 5, and 12 months of age who received Hib-TT combined with a bacteriocin-type B vaccine (Hib-TT) and compared immunocompetent children and Hib Antibody Concentrations in Unimmunized Children The authors inoculated 85 infants (vaccinated at 3,5 and 12 months of age) with Hib-TT in 1987, with 40 infants receiving 7.5 μg of Hib capsular polysaccharide per dose. And the other 45 received 15 μg of Hib.The results showed that at 30 months, the geometric mean concentrations of Hib antibodies (GMC) were 0.92 μg / ml and 1.69 μg / ml, respectively, and 97% of the children had higher antibody concentrations than the recommended (0.15 μg / ml) and 51% of the children had antibody concentrations above 1.0 μg / ml.The authors tested Hib antibodies against 70-year-old children at 6 years of age and selected 85 non-Hib- TT and Hib-infected children as a control.