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Objective Along with the development of gastric acid assays, 24 hour intragastric pH monitoring has become an important method in the study on physiologic secretion of gastric juice To study the influence of age on 24 hour intragastric pH rhythm, the effect of different ages on circadian patterns of intragastric pH rhythm, the effect of different ages on circadian patterns of intragastric pH was studied using 24 hour pH monitoring Methods Eighty asymptomatic volunteers, including 51 aged 60-82 (average 71 years) and 29 at 18-28 (average 21 years) were chosen after thoroughly screening by medical history, physical examination, blood biochemical assays and gastro endoscopy showing no mucosal erosion nor peptic ulcer Chronic superficial gastritis was, however, diagnosed in 16 and chronic atypical gastritis of gastric antrum in 35 of the elderly subjects endoscopically Thirty two patients, 20 younger aged 21-53, average 35 years and 12 elderly seen under the endoscopy showed active duodenal ulcer (DU) but had not been treated with anti ulcer drugs before pH monitoring Gastric pH was measured using monocrystal antimony electrode (MK Ⅲ by CTD Co , Sweden) The electrode was placed at 5-7?cm below the lower border of manometrically identified LES The 24 hour pH values were processed to obtain: baseline pH, 24 hour median pH, 24 hour mean pH, 24 hour plateau pH, median pH at night (21:00-7:00), and mean pH at night (21:00-7:00) Results There was no significant difference in the level of median pH (1 82 vs 1 44), baseline pH (1 09 vs 1 21) between the elderly and non elderly groups But the value of prandial plateau pH was higher in the elderly group than that in the non elderly group (4 36 vs 3 14, P <0 05) Compared with 29 non elderly asymptomatic subjects, 45 elderly subjects (88 2%) had the similar level of 24 hour median pH The value of median pH at night in elderly patients with DU was lower than that in asymptomatic elderly subjects (2 15 vs 1 17, P <0 05) Patients with DU in different age groups had the similar values of 24 hour median pH and median pH at night Conclusion The age factor dose not influence the activity of intragastric hydrogen ion at fasting state
Objective Along with the development of gastric acid assays, 24 hour intragastric pH monitoring has become an important method in the study on physiologic secretion of gastric juice To study the influence of age on 24 hour intragastric pH rhythm, the effect of different ages on circadian patterns of the intragastric pH rhythm, the effect of different ages on circadian patterns of intragastric pH was studied using 24 hour pH monitoring Methods Eighty asymptomatic volunteers, including 51 aged 60-82 (average 71 years) and 29 at 18-28 (average 21 years) were chosen after thoroughly screening by medical history, physical examination, blood biochemical assays and gastro endoscopy showing no mucosal erosion nor peptic ulcer Chronic superficial gastritis was, however, diagnosed in 16 and chronic atypical gastritis of gastric antrum in 35 of the elderly subjects endoscopically Thirty two patients, 20 younger aged 21-53, average 35 years and 12 elderly seen under the endoscopy showe d active duodenal ulcer (DU) but had not been treated with anti ulcer drugs before pH monitoring Gastric pH was measured using monocrystal antimony electrode (MK III by CTD Co, Sweden) The electrode was placed at 5-7? cm below the lower border of manometrically identified LES The 24 hour pH values were processed to obtain: baseline pH, 24 hour median pH, 24 hour mean pH, 24 hour plateau pH, median pH at night (21: 00-7: 00), and mean pH at night (21: 00-7: 00) Results There was no significant difference in the level of median pH (1 82 vs 1 44), baseline pH (1 09 vs 1 21) between the elderly and non elderly groups But the value of prandial plateau pH was higher in the elderly group than that in the non elderly group (4 36 vs 3 14, P <0 05) Compared with 29 non elderly asymptomatic subjects, 45 elderly subjects (88 2%) had the similar level of 24 hour median pH The value of median pH at night in elderly patients with DU was lower than that in asym ptPatients with DU in different age groups had the similar values of 24 hour median pH and median pH at night Conclusion The age factor dose not influence the activity of intragastric hydrogen ion at (2 15 vs 1 17, P <0 05) fasting state