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系统性红斑狼疮(SLE)是自身免疫介导的,以免疫性炎症为突出表现的弥漫性结缔组织疾病~([1])。狼疮性肾炎(LN)是SLE合并双肾不同病理类型的免疫性损害,同时伴有明显肾脏损害临床表现的一种疾病~([2])。通过肾穿刺活检,SLE患者的肾脏病理损害率几乎为100%~([3])。临床上将Ⅲ型、Ⅳ型、Ⅴ型以及Ⅲ+Ⅴ型及Ⅳ+Ⅴ型狼疮性肾炎定义为重症狼疮性肾炎(SLN)~([4-5])。相关文献报道,5%~20%的SLN患者在10年
Systemic lupus erythematosus (SLE) is an autoimmune-mediated, diffuse connective tissue disease characterized by autoimmune inflammation (1). Lupus nephritis (LN) is a disease associated with different pathological types of SLE and renal pathology, accompanied by a clear clinical manifestations of renal damage ~ ([2]). Through the renal biopsy, SLE patients with renal pathological damage rate of almost 100% ~ ([3]). Clinical Ⅲ, Ⅳ, Ⅴ and Ⅲ + Ⅴ and Ⅳ + Ⅴ type lupus nephritis is defined as severe lupus nephritis (SLN) ~ ([4-5]). Related literature reports, 5% to 20% of patients with SLN in 10 years