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目的:观察不同粗细毫针刺激对小鼠胃肠功能的影响.方法:将18只昆明种小鼠随机分为0.25 mm细针组、0.35 mm粗针组和对照组,每组6只,每天于固定时间分别刺激足三里穴,连续5天.通过检测小鼠肠内容物碳末推进距离,观察不同粗细毫针刺激对小鼠胃肠排空功能的影响.结果:三组碳末推进率比较,针刺组明显大于对照组(P<0.05).粗针组大于细针组,但没有统计学意义(P>0.05). 结论:针刺可以提高小鼠胃蠕动功能,不同粗细针针刺对小鼠胃肠功能影响没有明显差异.,Objective: To observe the effects of needles with different diameters on the gastrointestinal function in mice. Methods: Eighteen Kunming mice were randomly divided into group of 0.25 mm needle, group of 0.35 mm needle, and control group. The acupoint of Zusanli (ST 36) was needled once a day for 5 days. The effects of needles with different diameters were observed by measuring the distance of the carbon moved in the intestine. Results: The distance of the carbon moved in the intestine was longer in the acupuncture group than in the control group (P<0.05), and it was longer in the group of 0.35 mm needle than in the group of 0.30 mm needle, there was no significant difference (P>0.05). Conclusion: Acupuncture treatment can enhance the peristalsis function of stomach and intestine in mice. The diameter of needle has no effect on the gastrointestinal function.