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目的 通过对系统性红斑狼疮 (SLE)患者尿视黄醇结合蛋白 (RBP)的测定 ,探索一种非创伤性敏感的实验指标 ,监测SLE患者早期的肾脏损害。方法 将确诊为SLE的患者分为两组 ,进行肾穿刺 ,了解其病理情况 ,测定并分析病理改变 ,尿 β2 -微球蛋白、尿视黄醇结合蛋白等指标。结果 在尿蛋白及肾小球功能正常的SLE病人 ,RBP已较对照组显著升高 (P <0 0 5 ) ,组织学存在明显的肾小管间质病变 (IAI≥ 3) ,病人组中其尿RBP及 β2 MG明显增加 (P <0 0 5 )。结论 RBP可作为SLE病人肾脏损害的早期诊断指标 ,可反映其病理损害的程度 ,且RBP较 β2 MG更敏感、更早期地反映肾小管间质的功能变化 ,为狼疮肾早期诊断提供一个非创伤性的检测指标。
Objective To explore a non-invasive and sensitive experimental index for the detection of urinary retinol binding protein (RBP) in patients with systemic lupus erythematosus (SLE) and to monitor the early renal damage in SLE patients. Methods The patients diagnosed as SLE were divided into two groups. The renal puncture was performed to understand the pathological changes. The pathological changes, urinary β2 - microglobulin and urinary retinol binding protein were determined and analyzed. Results In SLE patients with normal urinary protein and glomerular function, RBP was significantly higher than that of the control group (P <0.05), histological manifestations of tubulointerstitial lesions (IAI ≥ 3) Urinary RBP and β2 MG increased significantly (P <0 05). Conclusions RBP can be used as an early diagnostic indicator of renal damage in SLE patients and can reflect the extent of pathological damage. RBP is more sensitive than β2 MG and earlier reflects the functional changes of tubulointerstitium, providing a noninvasive Sexual detection index.