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为了解ＥＢ病毒在中线Ｔ细胞淋巴瘤中的感染情况，作者对遵义地区４６例中线Ｔ细胞淋巴瘤进行ＥＢＶ检测，用聚合酶链反应检测ＥＢＶ特征性的ＤＮＡ序列（ＥＢＶＤＮＡ），用ＲＮＡ原位杂交法检测ＥＢＶ编码的ＲＮＡ（ＥＢＥＲ１／２）。结果：ＥＢＶＤＮＡ阳性率为７６．１％（３５／４６）；ＥＢＥＲ１／２阳性率为６７．４％（３１／４６）。鼻腔、鼻咽、口咽Ｔ淋巴瘤ＥＢＥＲ１／２阳性率分别为８８．９％（１６／１８）、７１．４％（５／７）、４７．６％（１０／２１）。在多形细胞性淋巴瘤中，中多形和大多形细胞性ＥＢＥＲ１／２阳性率为８０．０％（１６／２０），小多形细胞性为７３．３％（１１／１５）。结果表明ＥＢＶ感染与中线Ｔ淋巴瘤关系密切，它在该肿瘤的发病中可能起重要作用，中线Ｔ淋巴瘤的ＥＢＶ感染率与解剖学部位有关，多形细胞性淋巴瘤ＥＢＶ感染率较高，特别是中多形和大多形细胞性
To understand the infection of Epstein-Barr virus in midline T-cell lymphoma, the authors performed EBV detection on 46 cases of T-cell lymphoma in the central area of Zunyi. Polymerase chain reaction was used to detect EBV DNA and use RNA in situ. The EBV-encoded RNA (EBER1/2) was detected by hybridization. Results: The positive rate of EBV DNA was 76.1% (35/46); the positive rate of EBER1/2 was 67.4% (31/46). The positive rates of EBER1/2 in nasal, nasopharyngeal, and oropharyngeal T lymphoma were 88.9% (16/18), 71.4% (5/7), and 47.6% (10/21), respectively. In pleomorphic lymphomas, the positive rate of EBER1/2 in polymorphic and polymorphic cells was 80.0% (16/20), and the small polymorphism was 73.3% (11/15). The results show that EBV infection is closely related to midline T lymphoma, and it may play an important role in the pathogenesis of this tumor. The EBV infection rate of midline T lymphoma is related to the anatomic site, and the EBV infection rate of pleomorphic lymphoma is high. Especially in the polymorphous and polymorphous cellularity