不同病因的妊娠晚期肝损害对妊娠结局的影响

来源 :中国妇幼保健 | 被引量 : 0次 | 上传用户:fmwksf
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:分析不同病因的妊娠晚期肝损害对妊娠结局的影响。方法:将2010~2012年在南通地区多家医院产科住院分娩的486例妊娠晚期肝损害患者按照不同病因进行分组,并随机选取同期肝功能正常的230例孕产妇作为对照组,比较不同病因的妊娠晚期肝损害对妊娠结局的影响。结果:486例资料完整的妊娠晚期肝损害患者中,妊娠期肝内胆汁淤积症(ICP)组剖宫产、早产、胎儿宫内窘迫及胎膜早破发生率均高于对照组,差异均有统计学意义(P<0.05);重度子痫前期组剖宫产、产后出血、胎儿宫内窘迫及早产发生率与对照组相比,差异均有统计学意义(P<0.05);妊娠期急性脂肪肝(AFLP)组共9例患者,其中孕产妇死亡2例,围产儿死亡2例;HELLP综合征组有1例胎死宫内;妊娠期病毒性肝炎(VHP)组胎儿宫内窘迫发生率高于对照组(P<0.01);非酒精性脂肪肝(NAFLD)、胆系疾病、感染中毒性及病因不明组的各项妊娠结局与对照组相比,差异均无统计学意义(P>0.05)。结论:ICP主要增加围产儿不良事件的发生,对孕产妇无明显不良影响;重度子痫前期对母婴均存在明显不良影响;轻中度VHP对母婴影响甚微;NAFLD对母婴无明显影响;而AFLP病情凶险,会增加母婴死亡的风险。 Objective: To analyze the different etiology of late pregnancy induced liver damage on pregnancy outcome. Methods: A total of 486 pregnant women with pregnancy-induced liver damage who were hospitalized in hospitals of Nantong from 2010 to 2012 were divided into different causes according to different causes. 230 pregnant women with normal liver function during the same period were randomly selected as the control group, Effect of liver damage in late pregnancy on pregnancy outcomes. Results: The incidence of cesarean section, prematurity, fetal distress and premature rupture of membranes in 486 pregnant women with incomplete pregnancy was significantly higher than that of the control group (P <0.05). The incidences of cesarean section, postpartum hemorrhage, fetal distress and preterm birth in severe preeclampsia group were significantly different from those in control group (P <0.05). Pregnancy Acute fatty liver (AFLP) group of 9 patients, including maternal death in 2 cases, 2 cases of perinatal death; HELLP syndrome group 1 case of fetal death; viral hepatitis during pregnancy (VHP) group of fetal distress (P <0.01) .Non-alcoholic fatty liver disease (NAFLD), gallbladder disease, infectious toxicity and unexplained group of pregnancy outcomes compared with the control group, the difference was not statistically significant ( P> 0.05). CONCLUSION: ICP mainly increases the incidence of perinatal adverse events without significant adverse effects on pregnant women; severe preeclampsia has obvious adverse effects on both mother and infant; mild to moderate VHP has little effect on mother and infant; NAFLD has no obvious effect on maternal and infant Affect; and AFLP dangerous, will increase the risk of maternal death.
其他文献
通过吻合器痔上黏膜环切钉合、肛垫复位固定术(PPH)与肛垫保存术治疗重度环状痔各35例,术后2个月至2年随访观察,比较两组的临床疗效.PPH组在手术时间、术后疼痛指数、术后出
采用改良术式治疗环状混合痔伴直肠下段黏膜松弛176例,疗效满意,现报告如下.rn临床资料:本组男95例,女81例;年龄30~68岁,平均48.3岁;病程1.5~18年,平均11.2年.35例伴内痔出血.
目的:探讨子痫前期三维能量多普勒超声(3D-PDU)和产后胎盘中MMP-2、TIMP-2蛋白含量及蛋白阳性表达强度的关系。方法:选取在医院产科就诊的门诊及住院孕妇60例,其中正常晚期妊
目的:探讨视黄醇结合蛋白4(RBP4)与妊娠期高血压疾病的相关性。方法:选取2009年1月~2012年12月在该院住院分娩的单胎妊娠妇女89例,其中43例妊娠期高血压疾病妇女为A组,46例正
期刊
@@
探讨国产吻合器痔上黏膜环切术(PPH)的方法、疗效、适应症、注意事项及需改进措施.经肛门镜下采用33mm国产吻合器切除重度脱垂痔16例,直肠黏膜脱垂3例.平均手术时间20~25min,
国际临床骨密度学会( International Society for Clinical Densitometry , ISCD )和国际骨质疏松基金会( International Osteoporosis Foundation ,IOF)于2010年11月14日在罗马尼
针对近年高等教育高速发展形成高校多校区办学的现状,校园文化建设发展相对滞后,就数字化校园网络信息化与校园文化建设对师生进行问卷调查并分析结果.探讨了多校区建设数字
我院经骶管一次性注入丁丙诺啡注射液0.3mg,用于肛肠病术后镇痛,取得满意效果,现报告如下.rn临床资料:经骶管麻醉行肛肠病手术60例,ASA Ⅰ~Ⅱ级,年龄20~74岁,体重41~80kg.排除心
探讨中药配合吻合器痔上黏膜环切术(PPH)治疗嵌顿痔的临床疗效.采用中药加味槐花汤配合PPH治疗嵌顿痔30例和对照组24例的治疗效果进行分析比较.治疗组和对照组总有效率均为10
近年来,我们运用CO2激光行内括约肌侧切术治疗肛裂98例,取得满意疗效,现报告如下.rn临床资料:本组男35例,女63例;年龄18~46岁;病程3个月至20年.急性肛裂12例,慢性肛裂合并裂痔