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目的探讨空通气孔同源框2(EMX2)和E-钙黏蛋白(E-cadherin)在食管鳞癌(ESCC)中的表达及其临床意义。方法采用免疫组织化学法检测45例经石蜡包埋的ESCC组织(肿瘤组)及45例癌旁正常食管鳞状上皮组织(正常组)中EMX2和E-cadherin的表达情况,分析其表达与患者临床病理特征及预后的关系。结果 EMX2和E-cadherin在ESCC组织中的表达均明显低于正常食管组织。EMX2的表达强度与肿瘤的分期、分化程度及淋巴结转移情况之间的差异有统计学意义;E-cadherin的表达强度与肿瘤浸润深度、分期、分化程度及淋巴结转移情况之间的差异有统计学意义。此外,ESCC组织中EMX2与E-cadherin的表达呈正相关(r=0.582,P<0.01),且EMX2低表达组和E-cadherin低表达组的5年生存率均低于高表达组,差异均有统计学意义。同时,EMX2和Ecadherin共同低表达是影响ESCC患者预后的独立因素(P<0.01)。结论 EMX2与E-cadherin在ESCC组织中异常低表达,且呈现较好的相关性。联合检测二者的表达对ESCC患者的预后评估和治疗指导具有很大的临床价值。
Objective To investigate the expression of EMX2 and E-cadherin in esophageal squamous cell carcinoma (ESCC) and its clinical significance. Methods Immunohistochemistry was used to detect the expression of EMX2 and E-cadherin in 45 cases of ESCC tissues (tumor group) and 45 cases of adjacent normal esophageal squamous epithelium (normal group), and the correlation between the expression of EMX2 and E-cadherin Clinical and pathological features and prognosis. Results The expression of EMX2 and E-cadherin in ESCC tissues were significantly lower than that in normal esophageal tissues. EMX2 expression intensity and tumor stage, degree of differentiation and lymph node metastasis was statistically significant difference between the expression of E-cadherin and tumor invasion depth, stage, degree of differentiation and lymph node metastasis were statistically significant significance. In addition, the expression of EMX2 and E-cadherin in ESCC was positively correlated (r = 0.582, P <0.01), and the 5-year survival rates of EMX2 low expression group and E-cadherin low expression group were lower than those in high expression group There is statistical significance. At the same time, the common low expression of EMX2 and Ecadherin was an independent factor affecting the prognosis of patients with ESCC (P <0.01). Conclusions EMX2 and E-cadherin are abnormally low expressed in ESCC tissues and show a good correlation. Joint detection of the expression of both ESCC patients prognosis evaluation and treatment guidance has great clinical value.