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业已证实,甲胎蛋白(AFP)低浓度持续阳性(低持阳)者是原发性肝癌(PHC)的高危人群。这部份对象的免疫机能状况,与PHC的关系,至今国内外未见系统报道。本文采用血清细胞、体液免疫和补体等检测,对此问题进行初步分析。现将结果报告于后。 对象和方法 1.对象及诊断标准:AFP低持阳指在普查和肝病随访中发现AFP血凝法1:10*～1:100+或火箭法50～200 ng/ml,对流法阴性,检测三次以上,时间持续二个月以上,排除妊娠,其他恶性肿瘤临床不能确诊为PHC者86例,其中男62例,女24例,中位年龄43岁,均系门诊随诊者。 PHC系根据全国通用的诊断和分期标准。共116例。其中男86例,女30例,中位年龄47岁。早(Ⅰ)期14例,中(Ⅱ)期77例,晚(Ⅲ)期25例。均系住院病例。其中72例经组织学/细胞学证实为肝细胞癌。
It has been confirmed that patients with persistently low levels of alpha-fetoprotein (AFP) (low retention) are at high risk for primary liver cancer (PHC). The immune function status of this group of subjects and the relationship with PHC have not been systematically reported at home and abroad. This paper uses serum cells, humoral immunity and complement tests to conduct a preliminary analysis of this issue. The results are reported later. Subjects and Methods 1. Subjects and diagnostic criteria: AFP low holding positive refers to the AFP hemagglutination assay at 1:10* to 1:100+ or rocket method 50 to 200 ng/ml in the follow-up of general and liver diseases. The convection method is negative. More than three times, the duration of more than two months, the exclusion of pregnancy, other malignant tumors can not be diagnosed with PHC in 86 cases, including 62 males and 24 females, the median age of 43 years old, were out-patient follow-up. The PHC is based on the nationwide diagnostic and staging criteria. A total of 116 cases. There were 86 males and 30 females with a median age of 47 years. There were 14 cases in early (I) phase, 77 cases in middle (II) phase, and 25 cases in late (III) phase. All hospitalized cases. Of these, 72 cases were histologically/cytologically confirmed as hepatocellular carcinoma.