论文部分内容阅读
[目的]观察青蒿素对急性炎症的抑制作用.[方法]采用二甲苯诱导制作小鼠耳壳肿胀模型,分别给予大、中、小剂量青蒿素,测定小鼠耳壳肿胀度,并计算肿胀抑制率;用角叉菜胶诱导建立大鼠足肿胀模型,检测大鼠至炎5h时肿胀足中的前列腺素含量;给小鼠尾静脉注射0.5%(体积分数)伊文思蓝0.01mL/g,随后腹腔注射给予小鼠醋酸引起腹腔毛细血管通透性增高,检测小鼠腹腔内的伊文思蓝含量.[结果]青蒿素大、中、小剂量组二甲苯所致小鼠耳壳肿胀程度明显降低,与正常对照组比较差异均具有统计学意义(P<0.05,P<0.01);青蒿素大、小剂量组肿胀足中前列腺素含量明显降低,与正常对照组比较差异均有统计学意义(P<0.05,P<0.01);青蒿素能明显抑制醋酸所致小鼠腹腔毛细血管通透性增高(P<0.01).[结论]青蒿素对急性炎症有明显的抑制作用,抗炎机制可能与前列腺素有关.
[Objective] To observe the inhibitory effect of artemisinin on acute inflammation. [Methods] The mouse ear swelling model was induced by xylene, and the large, medium and small doses of artemisinin were respectively administered to mice. The swelling inhibition rate was calculated. The rat model of paw edema induced by carrageenan was established. The content of prostaglandin in the swelling foot was measured 5h after the rats were infused. The mice were injected 0.5% (volume fraction) Evans Blue 0.01mL / g, followed by intraperitoneal injection of acetic acid in mice caused increased peritoneal capillary permeability, detection of Evans blue in mice intraperitoneal. [Result] Artemisinin small, medium and low doses of xylene-induced mouse ear The degree of swelling of the shell was significantly lower than that of the normal control group (P <0.05, P <0.01); the content of prostaglandin in the swelling foot of artemisinin large and small dose group was significantly lower than that of the normal control group (P <0.05, P <0.01). Artemisinin could significantly inhibit the increase of peritoneal capillary permeability in mice induced by acetic acid (P <0.01). [Conclusion] Artemisinin has obvious effect on acute inflammation Inhibition, anti-inflammatory mechanism may be related to prostaglandins.