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苯中毒的诊断目前仍以白细胞和血小板的下降为标准,为寻找更为敏感的生化指标,我们对小鼠作了亚慢性苯暴露试验。发现受试小鼠在白细胞尚属正常时,其体内谷胺甘肽过氧化物酶和超氧化物歧化酶的活力以及白细胞內过氧化脂质的含量就已发生了明显的改变。表明在苯申毒的早期诊断中各种抗氧化酶活力和白细胞中过氧化脂质的测定具有十分重要的理论及实际意义。
Benzene poisoning is still the diagnosis of leukopenia and platelets as the standard, in order to find more sensitive biochemical indicators, we made a sub-chronic benzene exposure test in mice. Found that the test mice in the leukocyte is still normal, the body of glutathione peroxidase and superoxide dismutase activity and the content of lipid peroxidation lipid has changed significantly. It indicates that the determination of various antioxidant enzymes and lipid peroxidation in leukocytes in the early diagnosis of benzene poisoning has very important theoretical and practical significance.