人生殖细胞染色体畸变率已成为目前人们非常感兴趣的研究课题。由于人卵难以获得,以及人精子染色体仅在受精后才能观察,所以要直接分析人类生殖细胞染色体结构是不可能的。1978年Rudak 等首次报告了用人精子使地鼠卵受精后对人精子染色体结 Human germ cell chromosome aberration rate has become a very interesting research topic. Because human eggs are difficult to obtain and human sperm chromosomes can only be observed after fertilization, it is impossible to directly analyze the chromosomal structure of human germ cells. In 1978, Rudak et al reported for the first time on human sperm chromosomes after fertilization with human sperm