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已知肯定能引起人体白血病的环境因子仅有γ射线照射和苯及其有关烃类。但是在1971年,作者注意到了一系列曾以细胞毒药物治疗的肿瘤患者发生白血病的报道,其中多为急性粒细胞性白血病(简称急粒)。早期报道的病例多数起病于骨髓瘤或慢性淋巴细胞性白血病治疗后,但目前已有许多急粒作为淋巴网细胞内瘤晚期终局的报道。由于部分患者,尤其是淋巴网状细胞肉瘤患者,还曾接受过放射治疗,因此细胞毒疗法的致白血病作用就很难加以肯定。此外,由于骨髓瘤和慢性淋巴细胞性
Only environmental factors known to cause human leukemia are gamma-ray exposure and benzene and its related hydrocarbons. However, in 1971, the authors noticed a series of reports of leukemia in tumor patients treated with cytotoxic drugs, most of them acute myeloid leukemia. Most of the early reported cases of onset of myeloma or chronic lymphocytic leukemia after treatment, but there are many acute particles as the end of lymphocytic intracellular tumor final report. Since some patients, especially patients with lymphoid reticulocytic sarcoma, have received radiation therapy, the leukemia effect of cytotoxic therapy is difficult to be affirmed. In addition, due to myeloma and chronic lymphocytic