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丙型肝炎病毒(hepatitis C virus,HCV)是导致慢性肝炎的主要病原之一~([1]),HCV感染后20%~30%患者能自主清除,近70%可发展为慢性感染~([2])。免疫应答过程中分泌的各种细胞因子在病毒性肝炎转归期起重要作用[3],白细胞介素10(interleukin 10,IL-10)和IL-12在宿主防御、免疫稳态中起重要调节作用。IL-10由Th2细胞、巨噬细胞和B淋巴细胞等
Hepatitis C virus (HCV) is one of the major pathogens causing chronic hepatitis ([1]). 20% -30% of patients with HCV infection can self-purify and almost 70% can develop chronic infection ~ ( [2]). Various cytokines secreted during the immune response play an important role in the prognosis of viral hepatitis [3]. Interleukin 10 (IL-10) and IL-12 play important roles in host defense and immune homeostasis effect. IL-10 is composed of Th2 cells, macrophages and B lymphocytes