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目的探讨抗甲状腺药物致粒细胞缺乏患者发生医院感染的病原菌分布及其耐药性,为临床选择敏感抗菌药物提供参考。方法选取2010年5月-2013年5月34例甲状腺药物致粒细胞缺乏发生医院感染患者为研究对象,分析感染病原菌的分布和对抗菌药物的耐药性,所有数据采用SPSS16.0软件进行统计分析。结果粒细胞缺乏症患者医院感染部位以呼吸道感染为主占41.18%,其次为泌尿系和皮肤软组织,分别占26.47%和11.76%;共分离病原菌42株,其中革兰阴性菌19株占45.24%、革兰阳性菌20株占47.62%、真菌3株占7.14%;革兰阳性菌中金黄色葡萄球菌对万古霉素和美罗培南耐药率最低,均为0;主要革兰阴性菌则对美罗培南、亚胺培南耐药率最低,均为0;对其他抗菌药物的耐药率均>20.00%。结论甲状腺药物致粒细胞缺乏合并医院感染以呼吸道常见,加强细菌培养、药敏试验,早期应用敏感抗菌药物至关重要。
Objective To investigate the distribution and drug resistance of pathogenic bacteria causing nosocomial infection in patients with anti-thyroid drug induced neutropenia, and to provide a reference for clinical selection of antimicrobial agents. Methods From May 2010 to May 2013, 34 cases of nosocomial infection caused by thyroglobulin in patients with thyroid gland deficiency were selected as research object. The distribution of infectious pathogens and drug resistance to antibiotics were analyzed. All the data were analyzed by SPSS16.0 software analysis. Results The majority of nosocomial infections in patients with agranulocytosis were respiratory tract infection, accounting for 41.18%, followed by urinary tract and skin soft tissue accounting for 26.47% and 11.76%, respectively. There were 42 pathogenic bacteria isolated, of which 19 strains were Gram-negative bacteria accounting for 45.24% , 20 strains of Gram-positive bacteria accounted for 47.62% and 3 strains of fungi accounted for 7.14%. Staphylococcus aureus had the lowest rate of resistance to vancomycin and meropenem, both of which were 0; Luo Pei Nan, imipenem lowest resistance rates were 0; resistance to other antibiotics were> 20.00%. Conclusions Thyroid gland granulocyte deficiency combined with nosocomial infection is common in respiratory tract. It is very important to strengthen bacterial culture and drug susceptibility testing and early use of sensitive antibiotics.