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MMP和TIMP之间平衡失调在细胞外基质降解中起着关键作用,同时在肿瘤细胞侵袭及早期转移等过程中具有重要作用。通过对MMPs、TIMPs在消化系统癌组织中表达的检测可以对其早期诊断、转移及预后判断提供重要指导作用。主要对MMPs中的MMP-2和MMP-9及TIMPs在消化系统肿瘤发生、进展及转移中的作用做了概述。
The imbalance between MMP and TIMP plays a key role in the degradation of extracellular matrix, and plays an important role in tumor cell invasion and early metastasis. The detection of MMPs and TIMPs in the digestive system can provide an important guide for their early diagnosis, metastasis and prognosis. It mainly summarizes the roles of MMP-2, MMP-9 and TIMPs in the pathogenesis, progression and metastasis of digestive system in MMPs.