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目的 探讨宫颈阴道分泌物中的胰岛素样生长因子结合蛋白 - 1(IGFBP - 1)在胎膜早破诊断中的价值。方法 应用免疫层析法检测 2 49例孕妇宫颈阴道分泌物中低磷酸化IGFBP - 1的含量。结果 IGFBP - 1诊断胎膜早破的敏感性为 93 8% ,特异性为 94 5 % ,阳性预测值为 97 6 % ,阴性预测值为 86 3 %。结论 检测宫颈阴道分泌物中的IGFBP - 1是诊断胎膜早破快速、准确的方法。
Objective To investigate the value of insulin - like growth factor binding protein - 1 (IGFBP - 1) in the diagnosis of premature rupture of membranes in cervical vaginal secretions. Methods The levels of low - phosphorylated IGFBP - 1 in cervical vaginal secretions of 499 pregnant women were detected by immunochromatography. Results The sensitivity and specificity of IGFBP - 1 in the diagnosis of premature rupture of membranes were 93.8%, 94.5%, 97.6% and 86.3% respectively. Conclusion Detection of IGFBP - 1 in cervical vaginal secretions is a rapid and accurate method for the diagnosis of premature rupture of membranes.