在281例因高血压而始用肼苯哒嗪(HZ)达51个月的患者中,测定了HZ引起狼疮综合征(LS)的实际发病率。用HZ治疗三年后LS的发病率为6.7％(95％可信限3.2～10.2％)。发病率与剂量有关,每日摄取50毫克者无一例发生,每日100毫克者为 The actual incidence of HZ-induced lupus syndrome (LS) was measured in 281 patients who started with hydralazine (HZ) for 51 months due to high blood pressure. The incidence of LS after three years of treatment with HZ was 6.7% (95% confidence interval 3.2 to 10.2%). Incidence and dose-related, daily intake of 50 mg were no one case, 100 mg per day were