【摘 要】
：
A new synthesized benzene nitrogen mustard was converted into glycosyl donor-trichloroacetimidate that was glycosylated with p-nitrophenol(glycosyl donors) to f
【机 构】
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Department of Clinical Laboratory,College of Traditional Chinese Medicine in Changchun
【基金项目】
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the Department of Jilin Province Technology,China
论文部分内容阅读
A new synthesized benzene nitrogen mustard was converted into glycosyl donor-trichloroacetimidate that was glycosylated with p-nitrophenol(glycosyl donors) to form β-lactosyl p-nitrobenzene under the protection of acetyl in a stereoselective manner,was prepared and evaluated for its cytotoxicity towards cultured K562 cell line.Methylthiazoy tetrazolium(MTT) assay,transmission electron microscopy(TEM),flow cytometry(FCM) and immunohistochemistry were utilized to explore the mechanisms of how the compound arrests the growth of HCT-T cells.This new synthesed benzene nitrogen mustard glucoside derivate(BNMGD) presented a lower toxicity to normal cells,but is significantly more toxic to K562 cells compared with nitrogen mustard,meanwhile it can induce the apoptosis of K562 cells.These results indicate that the new synthesized BNMGD can inhibit the growth of K562 cells and induce the apoptosis,and its eytotoxicity towards cultured K562 cell line is much more effective than that of nitrogen mustard.
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