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为了评价直接免疫荧光技术对药疹的诊断价值,作者回顾性地分析了41例药疹患者的临床、直接免疫荧光和皮肤病理学的表现。从这些患者共取皮肤活检标本46份,其中42份取自皮损部,2份取自损害周围的皮肤,2份取自未受累的皮肤,除作HE染色的常规皮肤病理检查外,4μm厚的冰冻切片分别用标记荧光素的山羊抗人IgG、IgM、IgA、C_3和纤维蛋白原抗体染色,进行直接免疫荧
In order to evaluate the diagnostic value of direct immunofluorescence for drug eruption, the authors retrospectively analyzed the clinical, direct immunofluorescence and skin pathology findings of 41 patients with drug eruption. Forty-six skin biopsies were taken from these patients, of which 42 were taken from the lesion, 2 from the skin surrounding the lesion, and 2 from the uninvolved skin. In addition to conventional skin pathology for HE staining, 4 [mu] m Thick frozen sections were stained with goat anti-human IgG, IgM, IgA, C_3 and fibrinogen antibodies labeled with fluorescein for direct immunofluorescence