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目的:分析白细胞介素–10(IL–10)、干扰素–γ(IFN–γ)的表达水平与念珠菌性阴道炎发病的相关性,为念珠菌性阴道炎的临床治疗提供参考。方法:选取郑州大学第五附属医院2015年2月至2016年2月收治的初次就诊的念珠菌性阴道炎21例患者为初发组,将1年内反复发病4次(含以上)的患者13例患者设为复发组,另外选取本院健康体检的20例患者作为对照组,患者接受ELISA法检测,观察不同组别内IL–10、IFN–γ的表达水平,并研究IL–10、IFN–γ的表达水平与念珠菌性阴道炎发病的关系。结果:初发组和复发组患者的阴道分泌物IL–10的表达水平显著高于对照组,复发组的阴道分泌物IL–10的表达水平显著高于初发组,组间存在差异有统计学意义(P<0.05);初发组与复发组的阴道分泌物IFN–γ的表达水平均显著高于对照组,差异有统计学意义(P<0.05),复发组与初发组的IFN–γ的表达水平差异无统计学意义(P>0.05);IL–10、IFN–γ的表达水平与念珠菌性阴道炎具有相关性。结论:IL–10、IFN–γ的表达水平会影响念珠菌阴道炎,与其发病和复发情况具有相关性。
Objective: To analyze the correlation between the expression of interleukin-10 (IL-10) and interferon-γ (IFN-γ) and the pathogenesis of Candida vaginitis and to provide a reference for clinical treatment of Candida vaginitis. Methods: Twenty-one patients with Candida vaginitis admitted from February 2015 to February 2016 in the Fifth Affiliated Hospital of Zhengzhou University were enrolled as the initial group. Patients with more than 4 episodes (including above) within one year The patients were recruited as relapse group. Twenty patients in our hospital were selected as the control group. The patients were examined by ELISA and the expression levels of IL-10 and IFN-γ in different groups were observed. The levels of IL-10, IFN The Relationship Between the Expression of Candida Vaginitis and Candida Vaginitis. Results: The expression of IL-10 in the vaginal discharge in the primary and recurrent group was significantly higher than that in the control group, and the level of IL-10 in vaginal discharge in the recurrent group was significantly higher than that in the primary group (P <0.05). The levels of IFN-γ in vaginal secretions in both primary and recurrent groups were significantly higher than those in control group (P <0.05) (P> 0.05). The levels of IL-10 and IFN-γ were correlated with Candida vaginitis. Conclusion: The expression levels of IL-10 and IFN-γ affect Candida vaginitis, which is correlated with the incidence and recurrence of Candida vaginitis.