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目的正常高值血压具有较高的发展成为高血压的危险性。本研究的目的是观察正常高值血压患者血浆中血管活性因子和抗氧化酶的变化,以探讨其在高血压治疗和预防方面的意义。方法根据 JNC-7诊断标准筛选病例并分为三组:正常血压组(NT 组)为74例正常血压健康人,男性38例,女性36例,平均年龄(47.15±7.77)岁;正常高值血压组(PH 组)为51例正常高值血压患者,男性29例,女性22例,平均年龄(47.82±5.16)岁;高血压组(EH 组)为71例原发性高血压患者,男性37例,女性34例,平均年龄(48.25±7.97)岁。抽取静脉血,离心后分别采用放免法和酶联免疫法测定血中的血管紧张素Ⅱ(AngⅡ)、内皮素(ET)、血管加压素(AVP)、降钙素基因相关肽(CGRP)、一氧化氮合成酶(NOS)、超氧化物岐化酶(SOD)和谷胱甘肽过氧化物酶(GPX)等含量。结果与 NT组相比,EH 组和 PH 组血中甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平明显升高(P<0.05);高密度脂蛋白胆固醇在 PH 组中降低,EH 组明显降低(P<0.05);AngⅡ、AVP 和 ET 在 EH 组和 PH 组均增高(P<0.05);CGRP 在 PH 组和 EH 组均下降(P<0.05;P>0.05);NOS 在三组之间无明显的差异;SOD 在 PH 和 EH 组明显下降(P<0.05;P<0.01)而 GPX 明显增高(P<0.05;P<0.01)。结论 PH 患者血中脂类物质、血管活性物质、抗氧化酶出现了异常变化,这会增加患高血压的可能性。为尽可能减少和防止其进展为高血压,应该对 PH 患者进行相应的治疗和控制。
The purpose of normal high blood pressure has a high risk of developing into high blood pressure. The purpose of this study was to observe the changes of plasma vasoactive factors and antioxidant enzymes in patients with normal high blood pressure to explore its significance in the treatment and prevention of hypertension. Methods According to the diagnostic criteria of JNC-7, the patients were divided into three groups: normotensive group (NT group), 74 normal healthy subjects, 38 males and 36 females, with an average age of 47.15 ± 7.77 years; The blood pressure group (PH group) consisted of 51 patients with normal high blood pressure, including 29 males and 22 females, with an average age of 47.82 ± 5.16 years. In the hypertensive group (EH group), 71 patients with essential hypertension were male 37 cases, 34 females, the average age (48.25 ± 7.97) years old. Blood samples were collected for venous blood and centrifuged. The levels of angiotensin Ⅱ, endothelin (ET), vasopressin (AVP) and calcitonin gene related peptide (CGRP) were measured by radioimmunoassay , Nitric oxide synthase (NOS), superoxide dismutase (SOD) and glutathione peroxidase (GPX). Results The levels of triglyceride, total cholesterol and low density lipoprotein cholesterol in EH group and PH group were significantly higher than those in NT group (P <0.05). The levels of high density lipoprotein cholesterol in PH group and EH group were significantly lower than those in NT group (P <0.05). The levels of AngⅡ, AVP and ET in EH group and PH group were significantly higher than those in PH group and EH group (P <0.05; P <0.05) (P <0.05; P <0.01), while GPX was significantly increased (P <0.05; P <0.01). Conclusion The abnormal changes of lipids, vasoactive substances and antioxidant enzymes in blood of PH patients may increase the possibility of hypertension. In order to minimize and prevent its progression to hypertension, PH patients should be treated and controlled accordingly.