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目的观察中药固本抑瘤Ⅱ号在晚期乳腺癌治疗中的作用。方法55例复发或转移性乳腺癌患者随机分为治疗组和对照组,两组均采用NP(去甲长春花碱+顺铂)方案化疗,治疗组同时加服中药固本抑瘤Ⅱ号。观察治疗前后瘤体变化、中医证候改善情况、肿瘤标记物和生活质量评分。结果治疗组肿瘤缓解率、临床获益率分别为50.0%和92.9%,对照组两指标分别为40.7%和81.5%;两组中医证候总评分比较差异无统计学意义,但治疗组在乏力、肢体麻木、腰膝酸软3个证候的改善及稳定率优于对照组(P<0.05或P<0.01);治疗后治疗组生活质量评分无明显变化,对照组呈现下降趋势;两组治疗后肿瘤标记物均有不同程度下降,其中治疗组甲胎蛋白下降水平较对照组更为明显,具有统计学意义(P<0.05)。结论固本抑瘤Ⅱ号在晚期乳腺癌的治疗中可以发挥增效减毒作用,益气活血解毒中药可能作为化疗增敏剂。
Objective To observe the role of traditional Chinese medicine Guben Yiliu Ⅱ in the treatment of advanced breast cancer. Methods Fifty-five patients with recurrent or metastatic breast cancer were randomly divided into treatment group and control group. Both groups were treated with NP (atorvastatin + cisplatin) regimen. The treatment group was given traditional Chinese medicine Guben Yixue Ⅱ. The changes of tumor before and after treatment, the improvement of TCM syndrome, tumor markers and quality of life were observed. Results The remission rate and clinical benefit rate of the treatment group were 50.0% and 92.9%, respectively. The two indexes of the control group were 40.7% and 81.5% respectively. There was no significant difference between the two groups in the total score of TCM syndromes, however, , Body numbness, waist and knees, three syndromes improvement and stability was better than the control group (P <0.05 or P <0.01); after treatment, the treatment group quality of life scores did not change, the control group showed a downward trend; two groups of treatment After the tumor markers were decreased to varying degrees, of which the treatment group decreased level of alpha-fetoprotein more obvious than the control group, with statistical significance (P <0.05). Conclusion Gubenyixiang Ⅱ in the treatment of advanced breast cancer can play a synergistic and attenuating effect, Yiqi Huoxue Huoxue Chinese medicine may be used as a chemosensitizer.