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目的:探讨恶性浆膜腔积液腔内注入卡铂(CBP)加白细胞介素蛳2(IL蛳2)的疗效及毒副反应。方法:将36例经病理组织学或细胞学确诊为恶性浆膜积液(其中胸腔组23例,腹腔组11例,心包组2例)的患者排净积液后注入卡铂加白细胞介素蛳2。结果:总有效率83.3 %,其中胸腔组87.0 %,腹腔组72.7 %,心包组100 %。完全缓解率分别为34.8 %、27.3 %、100 %。毒副反应主要是轻度胃肠道反应、骨髓抑制、肾毒性、发热畏寒,分别为22.2 %、11.1 %、11.1 %、5.6 %。胸腔组轻度胸痛4.3 %,腹腔组出现轻度腹痛18.2 %,肠粘连18.2 %,不完全性肠梗阻9.1 %。结论:卡铂加白细胞介素蛳2联合介入生物化疗治疗恶性浆膜腔积液是一个疗效高,毒副反应少的有效方法。
Objective: To investigate the efficacy and side effects of intrapleural injection of carboplatin (CBP) plus interleukin-2 (IL-2) in malignant serous effusion. Methods: Thirty-six patients diagnosed as malignant serosal effusion by histopathology or cytology (including 23 in the thoracic cavity group, 11 in the abdominal cavity group and 2 in the pericardial group) were treated with carboplatin plus interleukin蛳 2. Results: The total effective rate was 83.3%, of which 87.0% in the chest group, 72.7% in the abdominal cavity group and 100% in the pericardial group. The complete remission rates were 34.8%, 27.3% and 100% respectively. Toxic side effects were mainly mild gastrointestinal reaction, bone marrow suppression, nephrotoxicity and fever chills, which were 22.2%, 11.1%, 11.1% and 5.6% respectively. Mild chest pain in the thoracic group was 4.3%, mild abdominal pain in the abdominal cavity group was 18.2%, intestinal adhesion was 18.2% and incomplete ileus was 9.1%. Conclusion: The combination of carboplatin and interleukin-2 in combination with biochemical chemotherapy for malignant serous effusion is an effective and effective method with less toxic side effects.