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目的观察阿魏酸钠注射液对冠心病患者血浆内皮素(ET)、动脉脉搏波速度(PWV)的影响。方法将96例冠心病心绞痛病人按治疗方法的不同分为阿魏酸钠组(50例)及对照组(46例),阿魏酸钠组给予阿魏酸钠100 mg加入生理盐水250 ml,静脉滴注,1次/d,连续14 d。对照组给予复方丹参注射液20 ml静脉滴注,1次/d,连续14 d。观察2组血浆ET及PWV的情况。结果治疗后阿魏酸钠组血浆ET、PWV较对照组明显下降〔(43.7±15.2)vs(58.6±20.4)ng/L,(14.38±1.80)vs(16.35±1.39)m/s,P均<0.01〕。结论阿魏酸钠可明显使冠心病患者血浆ET及PWV下降,有降低ET释放、改善动脉弹性的作用。
Objective To observe the effect of sodium ferulate injection on plasma endothelin (ET) and arterial pulse wave velocity (PWV) in patients with coronary heart disease. Methods Ninety-six patients with coronary heart disease and angina pectoris were divided into two groups: sodium ferulate group (n = 50) and control group (n = 46) according to different treatment methods. Sodium ferulate group (n = Intravenous infusion, 1 / d, for 14 days. Control group was given compound Danshen injection 20 ml intravenous infusion, 1 time / d, continuous 14 d. Two groups of plasma ET and PWV were observed. Results After treatment, the levels of plasma ET and PWV in the sodium ferulate group were significantly lower than those in the control group 〔(43.7 ± 15.2) vs (58.6 ± 20.4) ng / L, (14.38 ± 1.80) vs (16.35 ± 1.39) m / <0.01]. Conclusion Sodium ferulate can obviously decrease the plasma ET and PWV in patients with coronary heart disease, reduce ET release and improve arterial elasticity.