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目的：观察尼扎替丁治疗老年胃食管反流病的疗效。方法：将１１６例老年胃食管反流病随机分为３组：Ａ组 ４０例８组 ３８例（组 ３８例，分别应用奥美拉唑 ２０ ｍｇ。尼扎替 丁 １５０ ｍｇ。雷尼替丁１５０ ｍｇ，ｂｉｄ × ４周；然后分别改为２０ ｍｇ、１５０ ｍｇ、１５０ｍｇ ｑｄ至 ６个月．于治疗 ４周、３月、６月后观察各组总有效率。结果：显示 Ｂ组 ４周、３月、６月总有效率分别为８１．５８％、８９．４７％。９４．４７％，与Ａ组相比（分别为８５．００％、９０．００％、９５．００％）无显著性差异（Ｐ＞０．０５）；而与Ｃ组相比（分别为 ６５．７９％。７６．７２％、７８．９５％）有显著性差异（Ｐ＜０．０５）。症状积分与总有效率结果一致。结论：尼扎替丁治疗老年胃食管反流病与奥美拉唑疗效相仿，优于雷尼替丁，且价廉、副作用少。
Objective: To observe the efficacy of nizatidine in the treatment of gastroesophageal reflux disease in the elderly. Methods: One hundred and sixty-six elderly patients with gastroesophageal reflux disease were randomly divided into three groups: 40 cases in group A, 38 cases in group 8 (group 38, omeprazole 20 mg, nizatidine 150 mg, ranitidine 150 mg, bid × 4 weeks, and then were changed to 20 mg, 150 mg, 150 mg qd to 6 months in the treatment of 4 weeks, 3 months and 6 months after the observation of the total effective rate of each group.Results: , And the total effective rates in March and June were 81.58%, 89.47% and 94.47%, respectively, compared with those in group A (85.00%, 90.00% and 95.00% respectively). (P> 0.05), but there was significant difference compared with C group (65.79%, 76.72% and 78.95%, respectively) (P <0.05) The total efficiency of the same results.Conclusion: Nizatidine in the treatment of senile gastroesophageal reflux disease and omeprazole efficacy is similar, better than ranitidine, and cheap, less side effects.