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目的:评价血府逐瘀汤联合西药治疗冠心病的临床疗效。方法:检索Medline、Pub Med、CNKI、万方数据库、CBM数据库,查找2010~2016年公开发表的血府逐瘀汤联合西药治疗与西医对照治疗冠心病的临床随机对照研究,2位检索员根据纳入与排除标准独立对文献进行筛选,提取资料并对纳入研究的方法学质量进行评价,运用Rev Man 5.3软件进行Meta分析。结果:纳入9项以血府逐瘀汤为主方治疗冠心病的临床随机对照研究。Meta分析显示,血府逐瘀汤对冠心病的临床疗效改善优于对照组[OR=3.84,95%CI(2.56,5.77),P<0.00001],心电图改善效果优于对照组[OR=2.83,95%CI(2.05,3.92),P<0.00001]。漏斗图显示存在发表偏倚。结论:血府逐瘀汤联合西药治疗冠心病优于西药常规,且具有较高的安全性。
Objective: To evaluate the clinical efficacy of Xuefu Zhuyu Decoction combined with Western medicine in treating coronary heart disease. Methods: A randomized controlled clinical trial of Xuefu Zhuyu Decoction combined with western medicine and western medicine in the treatment of coronary heart disease (CHD) from 2010 to 2016 was searched for Medline, Pub Med, CNKI, Wanfang database and CBM database. The inclusion and exclusion criteria were used to screen the literature independently, data were extracted and the methodology quality of the included studies was evaluated, and Meta-analysis was performed using RevMan 5.3 software. Results: Nine randomized controlled trials of Xuefu Zhuyu decoction in the treatment of coronary heart disease were included. Meta-analysis showed that Xuefu Zhuyu Decoction improved the clinical curative effect of coronary heart disease better than the control group [OR = 3.84,95% CI (2.56, 5.77), P <0.00001]. The improvement effect of ECG was better than that of the control group [OR = 2.83 , 95% CI (2.05, 3.92), P <0.00001]. Funnel chart shows the existence of publication bias. Conclusion: Xuefu Zhuyu Decoction combined with western medicine is superior to Western medicine in treating coronary heart disease and has higher safety.