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自Schally和Guillemin1971年分离和确定了黄体生成素释放激素(LHRH)结构后,各项研究已确立了这个10肽及其类似物用作治疗药物的地位。1972年后,LHRH激素结构的改变产生了1500种以上合成的竞争性和拮抗性类似物。一、LHRH及其类似物用于促生育 (一)在女性的效应 1.诱发排卵 (1)长期服用LHRH:1971年Kastin等报告1例继发性闭经曾用hMG治疗的妇女静脉注射从猪的下丘脑提纯的LHRH后妊娠。以后有很多报告,但总的妊娠率低,占所有病人的14.7%及治疗周期的11.1%。Belchetz报告后方知结果不好的原因有二,提出LHRH受体失敏/下调和LHRH脉冲式
Since Schally and Guillemin decomposed and characterized the LHRH structure in 1971, various studies have established the position of this 10-peptide and its analogues as therapeutic agents. After 1972, LHRH hormone structure changes produced more than 1500 kinds of synthetic competitive and antagonistic analogues. First, LHRH and its analogues for fertility (a) the effect of women 1. Induced ovulation (1) long-term use of LHRH: 1971 Kastin et al reported a case of secondary amenorrhea in women with hMG intravenously from pigs Hypothalamic Purification After LHRH Pregnancy. There have been many reports since, but the overall pregnancy rate is low, accounting for 14.7% of all patients and 11.1% of treatment cycles. There are two reasons why Belchetz reported poor results after the report, suggesting that LHRH receptor desensitization / down regulation and LHRH pulsation