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目的 分析中国健康志愿者与心血管病患者之间糖蛋白(GP)Ⅱb/Ⅲa受体外显子基因多态性的分布差异.方法 在前期健康志愿者研究的基础上,本研究以心血管病患者为研究对象,通过Sequenom Mass ARRAY?方法检测GPⅡb/Ⅲa受体编码基因ITGA2B和ITGB3的外显子基因突变位点,分析2组人群中ITGA2B和ITGB3基因位点分布的差异.结果 共检测18个位点,其中3个位于ITGA2B,15个位于 ITGB3,心血管病患者和健康志愿者单核苷酸多态性(SNP )间连锁关系相似. ITGB3 rs112188890 ( P <0.001 )、 rs11871447 (P<0.001)、rs4634(P<0.05)以及rs70940817 (P<0.001)在心血管病患者和健康志愿者2组间分布存在显著性差异.结论 GPⅡb/Ⅲa受体编码基因外显子上存在多个基因多态性位点,在中国人群均有分布.“,”Objective To investigate the differences in distribution of Glycoprotein (GP)Ⅱb/Ⅲa receptor exon polymorphisms between Chi-nese cardiovascular patients and healthy population .Methods Based on our previous study of healthy volunteers , this study used the method of Sequenom Mass ARRAY?to detect the exon mutation sites of ITGI2B and ITGB3 which encoding GPⅡb/Ⅲa receptor and analyzed the differences in distribution between the two populations .Results Eighteen sites were detected.Three variants in the ITGA2B locus and fifteen variants in the ITGB3 locus were identified.The linkage relationships between single nucleotide polymorphisms (SNPs) in cardiovascular patients and healthy population were similar. The genotypes of ITGB3 rs112188890 (P<0.001), rs11871447 ( P <0.001 ), rs4634 ( P <0.05 ), and rs70940817 ( P<0.001 ) were significantly different between cardiovas-cular patients and healthy population.Conclusion There are multiple polymorphic sites in the exons of ITGI2B and ITGB3 in Chinese population.