Enhanced Cd uptake and Zn depletion in rice grains and high potential for food Cd exposure by the high-yielding hybrid cultivars had been addressed.A field experiment was conducted in 2006 to determine the difference in grain Cd and Zn between cultivars.Total 110 cultivars including super rice and common hybrid rice cultivars were grown on a single paddy soil (Entic Haplaquept) with a neutral reaction and low total Cd content.Grain Cd and Zn concentrations were determined with graphite atomic adsorption spectrophotometer (GFAAS) and flame atomic adsorption spectrophotometer (AAS) respectively.Wide variation of Cd content in grain was determined in a range of 0.004-0.057 mg/kg, while the Zn content in a range of 10.25-30.06 mg/kg among the cultivars.Higher Cd but lower Zn concentration in grains of super rice cultivars was observed compared to the common hybrid ones.A highly significant positive linear correlation of grain Cd/Zn with grain Cd was found for super rice and common hybrid cultivars, meanwhile much higher slope for these hybrid cultivars than the reported non-hybrid cultivars was also observed.Using the limit value of the Chinese chemical guidelines for foods (MOHC and SSC, 2005), calculated potential risk of food Cd exposure with Zn hungry through subsistence diet intake was prominent with all the studied 110 hybrid rice cultivars, possessing high potential health problems for rice production in South China using the super rice cultivars.Breeding of genotypes of rice cultivars with low grain Cd and low Cd/Zn ratio is needed for rice production in acidic red soils where Cd bioavailability is prevalently high in South China.