目的:了解一起洗浴中心W135群脑膜炎奈瑟菌感染疫情，为有效防控流行性脑脊髓膜炎提供依据。方法:采用现场流行病学方法对杭州市某洗浴中心1例W135群脑膜炎奈瑟菌感染患者和105名密切接触者进行调查，并采集咽拭子进行细菌分离鉴定。结果:通过流行病学调查、临床症状和实验室检测结果，确诊患者为W135群流脑病例。在接受采样的103名密切接触者中，9人咽拭子样本分离到脑膜炎奈瑟菌，带菌率8.74%，其中1人鉴定为B群脑膜炎奈瑟菌感染。对密切接触者随访未出现后续病例。结论:杭州市首次确诊W135群流脑病例，密切接触者中分离出B群脑膜炎奈瑟菌，警示该地区流行性脑脊髓膜炎流行菌群已发生变化。“,”Objective:To investigate an epidemic of serogroup W135 n Neisseria meningitidis infections in a spa center, so as to provide references for effective disposals of the disease.n Methods:A field epidemiological method was conducted to investigate 1 patient with W135 invasive meningococcal infection and 105 close contacts in a spa center in Hangzhou, and throat swab specimens were collected for pathogen isolation and identification.Results:According to the results of epidemiological investigation, clinical symptoms and laboratory test, this patient was confirmed as a W135 meningococcal case. A total of 9 isolates of n Neisseria meningitidis were identified from the throat swab specimens of 103 close contacts who accepted sampling, with positive rate of 8.74%. Additionally, 1 case was identified as serogroup B infection and no other cases were confirmed subsequently.n Conclusions:This is the first W135 invasive meningococcal case detected in Hangzhou. n Neisseria meningitidis serogroup B is isolated from the close contacts, which warns that the epidemic strain of cerebrospinal meningitis in this area has changed.n