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采用免疫放射法测定了１１６例脑血管病患者血浆和血小板表面ＧＭＰ－１４０的变化。发现脑动脉硬化组、脑梗塞组和脑出血组血浆和血小板表面ＧＭＰ－１４０均高于正常对照组（Ｐ＜０．０１），且脑梗塞与脑出血急性期明显升高，恢复期降至脑动脉硬化组水平。血小板表面与血浆内ＧＭＰ－１４０呈显著正相关（Ｐ＜０．０１）。结果表明脑血管病患者急性期血小板活性增高，血浆和血小板表面ＧＭＰ－１４０浓度可作为判断血小板活化和破坏程度的指标。
The changes of plasma and platelet surface GMP-140 in 116 patients with cerebrovascular disease were measured by immunoradioassay. It was found that plasma and platelet surface GMP-140 levels in cerebral arteriosclerosis group, cerebral infarction group and intracerebral hemorrhage group were significantly higher than those in normal control group (P <0.01). Cerebral infarction and cerebral hemorrhage were significantly increased during acute phase, Cerebral arteriosclerosis group level. Platelet surface and plasma GMP-140 was significantly correlated (P <0.01). The results showed that patients with cerebrovascular disease increased acute platelet activity, plasma and platelet surface GMP-140 concentration can be used as an indicator of platelet activation and destruction.
