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以低模量钛合金(Ti35Nb和Ti35Nb15Zr)为阳极氧化基材,采用表面阳极氧化方法制备出铌元素和锆元素掺杂的非晶TiO2纳米管阵列,比较了掺杂前后纳米管的润湿性能与体外生物活性.实验结果表明,加入铌和锆元素可减小TiO2纳米管的管径,并有助于增大TiO2纳米管的长度.TiO2纳米管表现出与未氧化前的金属基材所不同的疏水行为.掺杂TiO2纳米管的润湿性随着掺杂元素的变化而变化,铌元素的掺杂可使TiO2纳米管的润湿性改善,铌元素和锆元素共同掺杂对润湿性的改善作用更明显.在模拟体液(SBF)中浸泡后,掺杂TiO2纳米管可快速诱导磷灰石的形成.铌锆元素共同掺杂的纳米管在初始浸泡阶段呈现较快的磷灰石沉积速率.上述研究结果表明,可以通过基材合金化设计来调控或修饰材料表面的亲水或疏水性能,从而探索掺杂TiO2纳米管的生物学性能。
Low-modulus titanium alloys (Ti35Nb and Ti35Nb15Zr) were used as anodized substrates. Niobium and zirconium-doped amorphous TiO2 nanotubes were prepared by surface anodic oxidation. The wettability of the nanotubes before and after doping And biological activity in vitro.Experimental results show that the addition of niobium and zirconium can reduce the diameter of TiO2 nanotubes and help to increase the length of TiO2 nanotubes.TiO2 nanotubes exhibit the same properties as those of unoxidized metal substrates Different hydrophobic behavior.The wettability of doped TiO2 nanotubes changes with the changes of doping elements, the doping of niobium elements can improve the wettability of the TiO2 nanotubes, niobium and zirconium element doping on the Run Moisture improvement is more obvious.Adding TiO2 nanotubes can rapidly induce the formation of apatite after soaking in simulated body fluid (SBF) .The nanotubes co-doped with niobium zirconium element exhibit faster phosphorus in the initial soaking phase Graystone deposition rate.The above results show that the biological properties of doped TiO2 nanotubes can be explored by modifying or modifying the hydrophilic or hydrophobic properties of the surface of the material through the substrate alloying design.