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目的 探讨急性脑梗死患者血清神经元特异性烯醇酶 (NSE)的变化及其临床意义。方法 采集6 9例脑梗死患者起病 3天内的血标本 ,用酶联免疫分析法测定血清 NSE含量 (其中 35例 2周时复测 )。结果脑梗死 3天内血清 NSE明显高于对照组及 2周时 (P<0 .0 0 1) ,血清 NSE含量与梗死灶大小、神经功能缺损程度明显正相关 (P<0 .0 0 1) ,与意识障碍明显负相关 (P<0 .0 0 1) ,临床疗效越差血清 NSE含量越高 (P<0 .0 0 1)。结论 脑梗死早期血清 NSE明显升高 ,血清 NSE含量与临床表现关系密切。
Objective To investigate the changes of serum neuron specific enolase (NSE) in patients with acute cerebral infarction and its clinical significance. Methods The blood samples of 69 patients with cerebral infarction within 3 days after onset were collected and serum NSE levels were measured by enzyme - linked immunosorbent assay (35 of them were retested at 2 weeks). Results Serum NSE in 3 days after cerebral infarction was significantly higher than that in control group and 2 weeks (P <0.01). Serum NSE level was positively correlated with infarct size and neurological deficit (P0.01) , And negatively correlated with disturbance of consciousness (P <0.01). The poorer the clinical efficacy was, the higher the serum NSE level was (P0.01). Conclusion The serum levels of NSE in the early stage of cerebral infarction are significantly increased, and the serum NSE levels are closely related to clinical manifestations.