作者曾证明,为了判断豚鼠皮肤因刺激剂造成的炎症的轻重,皮肤厚度测定是一个十分精确的方法。刺激剂引起的皮肤厚度的增加能被皮质类固醇所抑制。后来,作者又曾用此法研究外用非类固醇抗炎剂的作用。初步结果表明,水杨酸、乙酰水杨酸和消炎痛外用都能抑制炎症。众所周知,水杨酸可松解角质,使表皮蛋白变性,从而增加皮肤的通透性。因此,作者推想,水杨酸与氢化可的松并用可能会增加氢化可的松的穿透性,因而出现相加的抗炎作用。但试验结果适得其反,二药表现拮抗作用。各项试验结果如下:与单用氢化可的松相比,氢 The authors have shown that skin thickness determination is a very accurate method to determine the severity of inflammation in guinea pig skin due to irritants. Stimulant-induced increase in skin thickness can be inhibited by corticosteroids. Later, the author used this method to study the effect of topical non-steroidal anti-inflammatory drugs. Preliminary results show that salicylic acid, acetylsalicylic acid and indomethacin topically can inhibit inflammation. As we all know, salicylic acid can release keratin, epidermal protein denaturation, thereby increasing the permeability of the skin. Therefore, the authors hypothesize that the combination of salicylic acid and hydrocortisone may increase the penetration of hydrocortisone and thus add an anti-inflammatory effect. However, the test results are counterproductive, two drug antagonism. The results of the tests are as follows: hydrogen compared to hydrocortisone alone