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本文报导了用DNP诱发大鼠鼻腔鼻咽的癌前期模型及癌变,绝大多数癌发生于鼻腔,用20mg/kg体重的DNP皮下注射32次,154—210天可发生100％癌前病变,有50％发生癌,最早一例癌发生于160天,如果剂量不变,潜伏期延长至273—302天,癌发生率增至85.7％。用国产维甲酰胺(RI)有抑制癌变作用,发生率下降至38.4％,文献上未见报导。DNP除诱发鼻咽鼻腔癌变外,160—302天内亦能引起20％的动物发生食道癌。RI对DNP引起的食道癌变亦有明显的抑制作用。
This paper reports that the precancerous model and carcinogenesis of nasal nasopharynx induced by DNP in rats, the vast majority of cancers occur in the nasal cavity, with subcutaneous injection of DNP 20mg/kg body weight 32 times, 100% precancerous lesions can occur in 154-210 days. 50% of patients develop cancer. The earliest case of cancer occurred in 160 days. If the dose is not changed, the incubation period is extended to 273-302 days, and the cancer incidence is increased to 85.7%. The use of domestic retinamide (RI) inhibited the carcinogenesis, and the incidence was reduced to 38.4%, which was not reported in the literature. In addition to nasopharyngeal nasal cancer, DNP can cause esophageal cancer in 20% of animals within 160-302 days. RI also has a significant inhibitory effect on DNP-induced esophageal cancer.