依赖非特异性凝集素细胞溶解(LDCC)的机制,与细胞毒性T淋巴细胞(CTL)特异性识别并杀伤靶细胞的机制基本相同,为了阐明凝集素(ConA)在LDCC中的确切作用,曾提出了二种主要的模式,第一是由Bonavida等(1983)提出,认为ConA起着双重作用:1、“桥梁”作用,将CTL与靶细胞连接起来;2、“激活”作用,激活效应细胞CTL,以达杀伤靶细胞的目的.第二是由作者(1983)提出的,认为ConA通过横向作用, “改变”了靶细胞表面的成份(包括MHC决定簇),使CTL通过识别 The mechanisms that rely on nonspecific lectin cytolysis (LDCC) are basically the same as those of cytotoxic T lymphocytes (CTLs) that specifically recognize and kill target cells. To elucidate the exact role of lectins (ConA) in LDCC, The two main models, the first is proposed by Bonavida et al. (1983), suggest that ConA plays a dual role: 1. The role of the “bridge” in linking CTLs to target cells; 2. “Activation” , Activating effector cells CTL for the purpose of killing target cells.Secondly, by the author (1983), ConA is believed to “change” the composition of target cells (including the MHC determinant) by lateral action CTL by recognition