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Twist属于高度保守的碱性螺旋-环-螺旋结构的转录因子家族,在动物和人胚胎发育、诱导细胞移动及组织塑形中起主要作用。Twist是一种癌基因,与许多肿瘤有密切关系,其中与骨肉瘤发生、侵袭和转移也有重要关系。骨肉瘤是一种最常见的原发性恶性骨肿瘤,恶性程度高,愈后差,以截肢术为主的手术治疗是过去标准的治疗手段,随着近年来新辅助化疗、基因靶向治疗等非手术治疗的发展,保肢手术为骨肉瘤患者带来了新的希望。癌基因Twist的深入研究将为骨肉瘤的诊断、治疗及预后提供了一个新的靶点。
Twist is a family of highly conserved basic helix-loop-helix transcription factors that play a major role in animal and human embryonic development, in induction of cell migration and in tissue engineering. Twist is an oncogene that is closely related to many tumors, of which there is an important relationship with the occurrence, invasion and metastasis of osteosarcoma. Osteosarcoma is one of the most common primary malignant bone tumors, with high malignancy and poor prognosis. Surgical treatment based on amputation is the standard treatment in the past. With the development of neoadjuvant chemotherapy and gene-targeted therapies in recent years, And non-surgical treatment of development, limb salvage surgery for patients with osteosarcoma has brought new hope. In-depth study of oncogene Twist will provide a new target for the diagnosis, treatment and prognosis of osteosarcoma.