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目的探讨新生儿ABO溶血病发生率与孕妇IgG抗-A(B)抗体效价之间的关系。方法685例O型Rh阳性孕妇做IgG抗-A(B)效价检测,对其中112例有HDN危险的孕妇所生新生儿做ABO血型鉴定、Coomb’s试验以及游离和释放试验,以了解孕妇IgG血型抗体效价与ABO-HDN发病率之间的关系。结果685例O型孕妇IgG抗-A(B)效价<64、64、128、256和≥512各组分别占58.2%、20.6%、11.8%、6.2%和3.2%。112例母婴血型不合且产有有ABO-HDN危险的孕妇所生新生儿中共有25例HDN阳性,占22.3%;孕妇IgG抗-A(B)效价为64、128、256和≥512各组HDN阳性率分别为11.5%、25.0%、36.8%和44.4%(P<0.05)。结论ABO-HDN的发生率与孕妇IgG抗-A(B)效价成正相关。
Objective To investigate the relationship between the incidence of neonatal ABO hemolytic disease and the titer of IgG anti-A (B) antibody in pregnant women. Methods 685 O-positive Rh-positive pregnant women were tested for IgG anti-A (B) titer, and ABO blood group identification, Coomb’s test and free and release test were performed on 112 newborn infants born with HDN risk to understand the relationship between pregnant women IgG The relationship between the blood group antibody titer and the incidence of ABO-HDN. Results The titer of IgG anti-A (B) in 685 O pregnant women was 58.2%, 20.6%, 11.8%, 6.2% and 3.2% in each group <64,64,128,256 and ≥512. A total of 25 HDN positive cases were found in 112 neonates born to pregnant women who were born with ABO-HDN. Their IgG anti-A (B) titers were 64,128,256 and ≥512 The positive rates of HDN in each group were 11.5%, 25.0%, 36.8% and 44.4%, respectively (P <0.05). Conclusions The incidence of ABO-HDN is positively correlated with the IgG titer of anti-A (B) in pregnant women.