在正常哺乳动物基因组中,Y染色体上编码睾丸决定因子(TDF)的基因是雄性发育所必需的,否则发育成雌性。近来,已克隆了TDF基因,即ZFY;还发现人类染色体XP21—XP22.3区域的X不失活,将其定为ZFX。随即,作者对两名X染色体短臂有重复片段的46,XY的女性进行研究,检测ZFX位点是否包括在重复片段中,结果获得了一些关于ZFY和ZFX在性别决定中的作用方式的线索。 In the normal mammalian genome, the gene on the Y chromosome that encodes testis determinator (TDF) is required for male development, otherwise it develops into a female. Recently, the TDF gene, ZFY, has been cloned; it was also found that X of the human chromosome XP21-XP22.3 region was not inactivated and was designated as ZFX. Immediately thereafter, the authors investigated 46 female XY women with a repeat of the X-short arm and examined whether the ZFX locus was included in the repeat, resulting in some clues as to the mode of action of ZFY and ZFX in sex determination .