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目的探讨保妇康栓治疗女性生殖道人乳头瘤病毒感染的临床价值。方法选取2015年1月-2017年3月平凉市人民医院妇科门诊收治的196例合并HPV感染的宫颈病变患者为研究对象,随机分为观察组和对照组各98例,观察组患者采用保妇康栓治疗,对照组患者采用重组人干扰素α-2b凝胶治疗。疗程结束后,对两组患者HPV-DNA转阴率及临床效果进行比较。结果观察组患者治疗后总有效率高于对照组患者,差异有统计学意义(P<0.05)。观察组患者治疗后HPV-DNA转阴率为52.0%,高于对照组患者(36.7%),差异有统计学意义(P<0.05)。保妇康栓对轻度宫颈柱状上皮异位患者治疗的有效率高于中度、重度柱状上皮异位患者及CINⅠ级患者,对中度宫颈柱状上皮异位患者治疗的有效率高于重度柱状上皮异位患者及CINⅠ级患者,差异有统计学意义(P<0.05)。保妇康栓对轻度、中度宫颈柱状上皮异位患者治疗后HPV-DNA转阴率高于重度柱状上皮异位患者及CINⅠ级患者(P<0.05)。结论保妇康栓治疗合并HPV感染的宫颈病变患者疗效确切,能明显缓解临床症状、缩小宫颈柱状上皮异位面积,清除HPV病毒,其效果优于干扰素治疗,且保妇康栓应用方便、无毒、副作用,减轻了患者心理负担,值得在临床上推广应用。
Objective To investigate the clinical value of Baofukang suppository in treating female genital tract human papillomavirus infection. Methods A total of 196 cases of cervical lesions with HPV infection were selected from the gynecology clinic of Pingliang People’s Hospital from January 2015 to March 2017. The subjects were randomly divided into observation group and control group with 98 cases each. Kang suppository treatment, the control group of patients with recombinant human interferon α-2b gel treatment. After the end of treatment, the HPV-DNA negative rate and clinical effect of the two groups were compared. Results The total effective rate of observation group patients after treatment was higher than that of the control group, the difference was statistically significant (P <0.05). The HPV-DNA negative rate of observation group was 52.0% after treatment, which was higher than that of control group (36.7%), the difference was statistically significant (P <0.05). Baofukang suppository for patients with mild cervical columnar epithelial ectopic patients with treatment efficiency is higher than moderate and severe columnar epithelial ectopic patients and CIN Ⅰ level patients with moderate cervical columnar epithelial ectopic patients treated more efficiently than severe columnar Epithelial patients and CIN Ⅰ level patients, the difference was statistically significant (P <0.05). Baofukang Suppository had a lower rate of HPV-DNA negative conversion in patients with mild and moderate cervical columnar epithelial ectopic patients than those with severe columnar epithelial ectopic patients and CINⅠ patients (P <0.05). Conclusion Baofukang Suppository has the exact curative effect on patients with cervical lesions associated with HPV infection. It can significantly relieve the clinical symptoms, reduce the cervical columnar epithelial ectopic area, clear the HPV virus, the effect is better than interferon treatment, and Baofukang suppository is easy to use, Non-toxic, side effects, reduce the psychological burden on patients, it is worth to promote the clinical application.