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目的:研究在食管癌根治术患者中予以不同剂量右美托咪定的效果以及对认知功能的影响。方法:依据不同剂量右美托咪定将我院自2015年12月至2016年12月期间收治的66例食管癌根治术患者随机分为0.5μg/(kg·h)组(n=33)与1.0μg/(kg·h)组(n=33),将采取0.5μg/(kg·h)剂量患者作为0.5μg/(kg·h)组,将采取1.0μg/(kg·h)剂量组作为1.0μg/(kg·h)组,对比两组患者不同剂量右美托咪定麻醉之后指标变化情况。结果:1.0μg/(kg·h)组行食管癌根治术患者T3时刻血清SOD活性最高,两组患者T2时刻MDA均升高,1.0μg/(kg·h)组行T2MDA显著低于参照组,1.0μg/(kg·h)组T2时刻NES浓度显著低于0.5μg/(kg·h)组,0.5μg/(kg·h)组MMES评分(24.23±0.23)分,1.0μg/(kg·h)组MMES评分(29.64±0.84)分,对比差异显著且P<0.05,统计学存在意义。结论:1.0μg/(kg·h)剂量麻醉对于改善行食管癌根治术患者术后认知功能具备重要作用,值得广泛应用。
OBJECTIVE: To study the effects of different doses of dexmedetomidine on patients with esophageal cancer undergoing radical surgery and their effect on cognitive function. Methods: According to different doses of dexmedetomidine, 66 patients with esophageal cancer underwent radical surgery from December 2015 to December 2016 were randomly divided into 0.5μg / (kg · h) group (n = 33) (1.0μg / (kg · h)) and 0.5μg / (kg · h) 0.5μg / (kg · h) Group as 1.0μg / (kg · h) group, comparing two groups of patients after different doses of dexmedetomidine anesthesia changes in indicators. Results: Serum SOD activity was the highest at T3 in 1.0μg / (kg · h) group, MDA was increased at T2, and T2MDA in 1.0μg / (kg · h) group was significantly lower than that of reference group , The NES concentration in the 1.0μg / (kg · h) group at T2 was significantly lower than that in the 0.5μg / (kg · h) group and the MMES score (24.23 ± 0.23) and 1.0μg / (kg · H) group MMES score (29.64 ± 0.84) points, the difference was significant and P <0.05, statistically significant. Conclusion: 1.0μg / (kg · h) dose of anesthesia plays an important role in improving the postoperative cognitive function in patients undergoing esophagectomy. It is worth to be widely used.