目的　以河南省人口、经济和麻疹流行病学资料为基础 ,从经济学角度对强化免疫策略与两剂免疫策略进行比较和评价。方法　采用卫生经济学中成本 -效果分析方法 ,时间区间为1997～ 2 0 2 0年 ,效果指标为失能调整寿命损失年 (disabilityadjustedlifeyears,DALY) ,成本 -效果比(cost-effectivenessratio ,CER) =强化免疫策略与两剂免疫策略的费用差 /强化免疫策略与两剂免疫策略的效果差。结果　随年份的增长 ,CER呈下降趋势 ,从 2 0 13年起强化免疫策略有正效益。结论　强化免疫策略不仅在降低麻疹发病、阻断麻疹传播方面有很好的效果 ,在经济上也是合算的 Objective To compare and evaluate the two strategies based on epidemiological data of population, economy and measles in Henan Province from an economic point of view. Methods Using the cost-effectiveness analysis method in health economics, the time interval was from 1997 to 2020, and the effect indicators were disabilityadjustedlifeyears (DALY), cost-effectiveness ratio (CER) = The difference between intensive immunization strategy and two-dose immunization strategy / intensive immunization strategy and two-dose immunization strategy are poor. Results With the increase of years, the CER showed a downward trend. Since 2013, the strategy of boosting immunization has positive benefits. Conclusion Intensive immunization strategies are not only economically effective in reducing the incidence of measles but also in preventing the spread of measles