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目的观察益生菌联合三联疗法根除幽门螺杆菌(Hp)感染的临床效果。方法选取Hp感染患者196例,随机分为观察组和对照组各98例,对照组给予三联疗法,观察组给予益生菌联合三联疗法治疗,比较2组患者Hp根除率和不良反应发生率。结果观察组Hp根除率为84.7%,高于对照组的69.4%,差异有统计学意义(P<0.05)。观察组不良反应发生率为8.2%,低于对照组的21.4%,差异有统计学意义(P<0.01)。结论益生菌联合三联疗法治疗Hp感染,可显著提高Hp清除率,且不良反应发生率低,安全可靠,值得推广应用。
Objective To observe the clinical efficacy of probiotics combined with triple therapy in the eradication of Helicobacter pylori (Hp) infection. Methods 196 patients with Hp infection were randomly divided into observation group and control group, 98 cases in each group. The control group was given triple therapy. The observation group was treated with probiotics combined with triple therapy. Hp eradication rate and incidence of adverse reactions were compared between the two groups. Results The Hp eradication rate in the observation group was 84.7%, which was higher than that in the control group (69.4%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 8.2%, which was lower than 21.4% in the control group, with significant difference (P <0.01). Conclusions Probiotics combined with triple therapy for Hp infection can significantly improve the clearance rate of Hp, and the incidence of adverse reactions is low, safe and reliable, which is worth popularizing and applying.