论文部分内容阅读
目的：评价动脉内灌注尿激酶（ＵＫ）治疗急性缺血性脑卒中的安全性和疗效。材料与方法：在ＤＳＡ机下采用超选择性动脉内插管灌注ＵＫ治疗２２例急性脑卒中患者。平均发病时间１８．９小时，ＵＫ用量为３～９．５×１０５ＩＵ，灌注时间持续３０～６０分钟。结果：１０例患者即刻完全再通，其中１例术后１天重新闭塞。９例部分再通，３例未通。１３例脑血栓形成患者中８例完全再通，而９例脑梗塞患者仅２例完全再通，前者再通率高于后者。临床有效率６８．１８％，２例死亡。结论：超选择性动脉内灌注ＵＫ治疗急性缺血性脑卒中是一种安全可接受的方法，其疗效与栓子来源有关。
Objective: To evaluate the safety and efficacy of intra-arterial infusion of urokinase (UK) in the treatment of acute ischemic stroke. MATERIAL AND METHODS: Twenty-two patients with acute stroke were treated with super selective arterial cannulation of UK under DSA. The average onset time of 18.9 hours, UK dosage of 3 ~ 9.5 × 105IU, perfusion time lasted 30 to 60 minutes. Results: Ten patients were completely recanalized immediately. One of them recurred after one day. 9 cases recanalization, 3 cases failed. Of the 13 patients with cerebral thrombosis, 8 were completely recanalized, whereas only 9 of the 2 patients with cerebral infarction were completely recanalized. The former had a higher recanalization rate than the latter. Clinical efficiency of 68.18%, 2 patients died. CONCLUSIONS: Superselective intra-arterial infusion of UK for acute ischemic stroke is a safe and acceptable method and its efficacy is related to the source of emboli.