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0 引言 骨形成蛋白 (Bone Morphogenetic Protein,简称BMP) 2在骨肉瘤中有较高的表达并影响骨肉瘤的生物学活性 ,引起骨肉瘤的预后不良 .为了进一步研究 BMP2在骨肉瘤细胞中的作用机制并为探讨骨肉瘤反义核酸技术治疗的可行性 ,我们构建了反义 BMP2的逆转录病毒表达载体 .1
0 Introduction Bone morphogenetic protein (BMP) 2 is highly expressed in osteosarcoma and affects the biological activity of osteosarcoma, resulting in poor prognosis of osteosarcoma. In order to further study the role of BMP2 in osteosarcoma cells Mechanism and to explore the feasibility of osteosarcoma antisense technology, we constructed an antisense BMP2 retroviral expression vector.1