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目的 观察手术对老年高血压病患者血小板活化功能的影响。方法 选择 110例老年择期手术患者 ,按有无高血压病分成高血压病组和对照组 ,分别于手术前和手术后 30min抽肘静脉血送实验室 ,用流式细胞分析仪测定CD6 2P、CD6 3、CD4 1含量。结果 术前高血压病组患者的CD6 2P、CD6 3、CD4 1较对照组明显增高 ,差异有显著性意义(P <0 .0 5 ) ;术后 2组患者的CD6 2P、CD6 3、CD4 1较术前均明显增高 ,其中高血压病组更高 ,差异有显著性意义 (P<0 .0 1)。结论 手术更易激活老年高血压病患者的血小板功能 ,增加血栓性并发症的发生率 ,应注意围手术期的抗凝措施。
Objective To observe the effect of surgery on platelet activation in elderly hypertensive patients. Methods One hundred and ten elderly patients undergoing elective surgery were divided into hypertension group and control group according to the presence or absence of hypertension. Blood samples were collected from the elbow venous blood before operation and 30 minutes after the operation. CD6 2P, CD6 3, CD4 1 content. Results The levels of CD6 2P, CD6 3 and CD4 1 in patients with prehypertension were significantly higher than those in control group (P 0.05). The levels of CD6 2P, CD6 3, CD4 1 were significantly higher than preoperative, including hypertensive group was higher, the difference was significant (P <0.01). Conclusion Surgery is more likely to activate platelet function in elderly hypertensive patients and increase the incidence of thrombotic complications. Perioperative anticoagulation should be noted.