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目的:研究柽柳水提取物(aqueous extract of Tamarix chinensis,AETC)对佐剂性类风湿关节炎(adjuvant-induced arthritis,AA)大鼠模型的治疗作用。方法:利用大鼠足跖皮下注射弗氏完全佐剂建立AA大鼠模型,通过测量大鼠足跖肿胀度以及压力耐痛值对AETC的抗类风湿关节炎效果进行评价。结果:柽柳水提物给药治疗可明显减轻AA模型大鼠的足跖肿胀程度,同时明显提升模型大鼠的压力耐痛值。结论:柽柳水提物对佐剂性类风湿关节炎大鼠模型具有显著的抗炎和镇痛作用,治疗效果良好。
Objective: To study the therapeutic effect of aqueous extract of Tamarix chinensis (AETC) on rat model of adjuvant-induced arthritis (AA). Methods: A rat model of AA was established by subcutaneous injection of complete Freund’s adjuvant in rats’ feet. The effect of anti-rheumatoid arthritis on AETC was evaluated by measuring the degree of paw edema and pressure pain resistance. Results: Tamarix water extract administration can significantly reduce the degree of paw edema in AA model rats, and at the same time significantly improve the pressure pain resistance of model rats. Conclusion: Tamarix water extract has significant anti-inflammatory and analgesic effect on adjuvant rheumatoid arthritis rat model, and the treatment effect is good.