论文部分内容阅读
目的探讨儿童及青少年分化型甲状腺癌的临床病理特征。方法回顾性分析30例儿童及青少年分化型甲状腺癌患者的临床资料,并结合年龄和性别因素对分化型甲状腺癌的临床病理特征进行分析。结果甲状腺乳头状癌27例,甲状腺滤泡状癌3例,肿瘤平均直径为(2.56±1.1)cm。儿童组中淋巴结转移率92.3%(12/13),肺转移率46.2%(6/13);青少年组淋巴结转移率88.2%(15/17),肺转移率35.3%(6/17)。儿童组患者病灶更容易发生脉管癌栓、甲状腺被膜侵犯及甲状腺外侵犯,出现颈侧区淋巴结转移的几率更高,差异有统计学意义。结论儿童及青少年分化型甲状腺癌患者的侵袭性强,容易出现局部侵犯、淋巴结及远处转移,儿童患者比青少年患者侵袭性更强。
Objective To investigate the clinicopathological features of differentiated thyroid carcinoma in children and adolescents. Methods The clinical data of 30 patients with differentiated thyroid cancer in children and adolescents were retrospectively analyzed. The clinicopathological features of differentiated thyroid cancer were analyzed by age and gender. Results Thyroid papillary carcinoma in 27 cases, thyroid follicular carcinoma in 3 cases, the average tumor diameter was (2.56 ± 1.1) cm. The rate of lymph node metastasis was 92.3% (12/13) in children group and 46.2% (6/13) in lung metastasis group. The rate of lymph node metastasis in adolescent group was 88.2% (15/17) and lung metastasis rate was 35.3% (6/17). Lesions in children group were more prone to vascular thrombosis, thyroid capsule invasion and extrathyroidal invasion, the occurrence of cervical lymph node metastasis more likely, the difference was statistically significant. Conclusion Children and adolescents with differentiated thyroid cancer are highly invasive and prone to local invasion, lymph node and distant metastasis, children with aggressive than adolescent patients.