作为一种重要的生物活性分子,一氧化氮(Nitric Oxide,NO)参与体内一系列生理和病理条件下的生物过程,调节循环、神经、免疫等系统一系列的生理活动,如血管扩张、血管通透性、血小板粘附和聚集、神经信号传递、宿主防御反应等,同时也参与包括肿瘤在内的病理过程。随着对NO研究的深入,其与肿瘤生物学的关系日益受到关注,目前已明确NO是活化巨噬细胞杀伤肿瘤细胞时产生的毒性效应分子之一,然而大量的临床和实 As an important bioactive molecule, nitric oxide (NO) participates in a series of physiological and pathological biological processes in the body and regulates a series of physiological activities such as vasodilation, blood vessels Permeability, platelet adhesion and aggregation, nerve signaling, host defense response, but also involved in pathological processes, including tumors. With the deepening of NO research, its relationship with tumor biology has drawn increasing attention. It has been well established that NO is one of the toxic effector molecules activated by macrophages when they kill tumor cells. However, a large number of clinical and practical